Therapeutic Development

These resources leverage Northwestern’s expertise investigating the impact of genetics on drug efficacy to design personalized strategies for the treatment of kidney diseases.

Department of Pharmacology - Pharmacogenomics

Alfred L. George, Jr., MD, chair of the Department of Pharmacology and director of the Center for Pharmacogenomics, is a leading nephrologist scientist in pharmacogenomics.

Automated Eletrophysiology for High-Throughput Screening of Ion Channels

The Automated Electrophysiology Facility features a dual 384-well automated planar patch clamp system, along with additional automation for liquid handling (LabCyte Echo 550), high capacity cell electroporation (MaxCyte STX) and automated cell counting (Beckman ViCell).

This platform allows high fidelity, gigaseal capable, parallel recording of up to 768 ion channels, and can be adapted to record from many cell types relevant to kidney research, including podocytes, tubular epithelial cells, endothelial cells, immune cells and iPSC-derived cells.

Also visit the Cardiovascular Pharmacology page on the Department of Pharmacology site to learn more.

GMP Production Facility

This resource leverages the expertise of Northwestern Medicine’s Mathews Center for Cellular Therapy for producing and implementing clinical biologic and cellular therapies for the treatment of kidney diseases. Also visit our Core B services page for more information.

Chemistry of Life Processes Institute

Available to nephroHUB scientists, the Northwestern Chemistry of Life Processes Institute leverages the technologies professed by chemistry of life scientists to discover diagnostic methods and therapies for kidney diseases.